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microRNA调控内耳发育及听力损失的研究进展 |
丁璐, 刘洋, 刘静, 钟丽, 曹敬莲, 朱宝立
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南京医科大学公共卫生学院, 江苏南京 211166;东南大学公共卫生学院, 江苏南京 211189; 江苏省疾病预防控制中心职业病防治所, 江苏南京 210009
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摘 要: microRNA (miRNA)作为一类微小非编码RNA,通过RNA干扰(RNAi)信号通路来调控基因表达,在机体发育和疾病中发挥重要作用。基于此,本文一方面揭示miRNA在斑马鱼和小鼠的内耳发育过程中的表达状况和其重要作用,以此外推其在人类内耳中的功能;另一方面阐述了miRNA参与调控听力损失相关疾病表型中的最新进展,为探索如何更好地预防听力损失的发生及改善预后提供新的线索。 |
关键词: microRNA 内耳 听力损失 斑马鱼 小鼠 |
中图分类号: R764
文献标识码:
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基金项目: 江苏省医学领军人才项目(LJ201130) |
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Study progress on inner ear development and hearing loss regulated by miRNA |
Ding Lu, Liu Yang, Liu Jing, Zhong Li, Cao Jinglian, Zhu Baoli
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School of Public Health, Nanjing Medical University, Nanjing 211166, China
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Abstract: MicroRNA (miRNA) is a kind of small non⁃coding RNAs that regulate gene expression through RNA interfere(RNAi) pathway, play important roles in many developmental processes and disease courses. Based on these points, the review revealed the expression situation and its indispensible role of miRNAs in developmental process of inner ear in zebra fish and mouse, thereby extrapolating its effect in human inner ear function on one hand; on the other hand, the paper also showed the lastest advances of miRNAs on phenotype implicated regulating hearing loss⁃related diseases, thus provide some new clues for preventing hearing loss and improving its prognosis. |
Keywords: microRNA inner ear hearing loss zebra fish mouse |
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