| Abstract: Silica nanoparticles have been widely used in many fields, such as aviation, aerospace, military, food and medicine, etc., because of its unique physical and chemical properties, therefore, its toxicity and mechanism to human body have become a research hotspot nowadays. This paper synthesizes the latest research results at home and abroad in this field, including exposed environments to silica nanoparticles, ways of invasion into human body, toxicities to systems or organs such as respiratory, cardiovascular, reproductive, nervous, and kidney, etc., and the mechanisms such as oxidative stress, inflammatory reaction, DNA damage, organelle dysfunction, autophagy, apoptosis, epigenetic changes, etc. |
