摘 要: 肺纤维化是以成纤维细胞增殖、大量细胞外基质聚集,以及伴随炎症损伤、组织结构破坏为特征的一大类肺疾病的终末期改变;炎症反应在纤维化发病过程中尤其起到关键作用。白细胞介素-6( interleukin-6, IL-6)家族细胞因子作为促炎细胞因子或抗炎细胞因子参与肺部炎症反应,通过调控促纤维化因子分泌,激活信号传导通路,诱导成纤维细胞的增殖、分化,从而在肺纤维化进展中发挥重要作用。本文拟对IL-6家族细胞因子在肺纤维化中的作用与治疗研究进行综述,以供今后工作参考。 |
关键词: 肺纤维化 细胞因子 白细胞介素-6(IL-6) IL-11 IL-31 |
中图分类号: R135.2
文献标识码: A
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基金项目: 山东省自然科学基金(编号:ZR2022MH293);国家科技重大专项(新药创制重大专项)分题(编号:2018ZX09711001-011);山东省医学科学院医药卫生创新工程;山东省中医药科技发展计划(编号:2021M153 );山东第一医科大学学术提升计划(编号:2019QL001);济南市科技局临床医学科技创新计划(编号:202019109,202328069) |
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Role of IL-6 family cytokines in pulmonary fibrosis |
WANG Xinguang,BO Cunxiang,PAN Zhifeng
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Shandong First Medical University/Shandong Provincial Academy of Medical Sciences/Shandong Provincial Academy of Occupational Health and Occupational Medicine,Jinan, Shandong 250062,China
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Abstract: Pulmonary fibrosis is a major end-stage change of lung diseases characterised by proliferation of fibroblasts,large accumulation extracellular matrix accompanied with inflammatory damage and tissue structure destruction, while the inflammatory response especially plays a crucial role in the pathogenesis of fibrosis. The cytokines of interleukin-6(IL-6)family,as pro-inflammatory or anti-inflammatory cytokines,participate in pulmonary fibrosis response,and play an important role in the progerssion of pulmonary fibrosis by regulating the secretion of pro-fibrotic factors,activating signaling pathways, and inducing proliferation and differentiation of fibroblasts. This article aims to review the research progress on the role of IL-6 family cytokines in pulmonary fibrosis and its therapeutic effect in it for future reference in work. |
Keywords: pulmonary fibrosis cytokines interleukin-6(IL-6) IL-11 IL-31 |