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| 矽肺合并 Whipple 病的病例追踪分析 |
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徐沙, 李慧妍, 梅凤, 段家淼, 郑丽, 周爽, 彭菲菲, 凌瑞杰
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湖北省中西医结合医院/湖北省职业病医院/湖北省尘肺病与中毒临床医学研究中心, 湖北 武汉 430015
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| 摘 要: 对 1 例确诊为矽肺合并 Whipple 病的矽尘作业者的职业史、临床表现、影像学改变等临床资料进行回顾性分析。对于存在不明原因多系统损伤,出现发热、关节炎、关节痛、腹泻、体质量下降、肝脾肿大及腹水临床表现的病例, 应及早采用二代基因测序(NGS)技术检测,以早期明确诊断 Whipple 病。本例亦提示矽肺患者免疫功能降低,其罕见合并症应引起足够重视。 |
| 关键词: 矽肺 Whipple 病 二代基因测序(NGS)技术 |
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中图分类号: R135. 2
文献标识码: A
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| 基金项目: 湖北省尘肺康复站点常驻尘肺病患者生存质量调查及中医证候特点研究(JF2023-G25) |
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| Tracking analysis of diagnostic cases of silicosis combined with Whipple's disease |
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XU Sha, LI Huiyan, MEI Feng, DUAN Jiamiao, ZHENG Li, ZHOU Shuang, PENG Feifei, LING Ruijie
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Hubei Provincial Hospital of Integrated Chinese and Western Medicine/Hubei Provincial Hospital of Occupational Disease/Hubei Provincial Clinical Research Center for Pneumoconiosis and Poisoning, Wuhan, Hubei 430015, China
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| Abstract: The including occupational history, clinical manifestations, imaging changes and other clinical data of a case of silicosis worker diagnosed with Whipples disease were retrospectively analyzed. For cases with unexplained multi-system damage, presenting with clinical manifestations such as fever, arthritis, arthralgia, diarrhea, weight loss, hepatosplenomegaly and ascites, next-generation sequencing (NGS) technology should be adopted as early as possible for detection to confirm the diagnosis of Whipple's disease at an early stage. This case also suggests that the immune function of patients with silicosis is reduced, and its rare complications should be paid enough attention. |
| Keywords: silicosis Whipple disease next-generation sequencing (NGS) technology |
