细胞焦亡在尘肺肺纤维化中的作用

The role of cell pyroptosis in pneumoconiosis induced pulmonary fibrosis

关键词: 尘肺病  细胞焦亡  发病机制  肺纤维化

Keywords: pneumoconiosis  pyroptosis  pathogenesis  pulmonary fibrosis

摘 要: 尘肺肺纤维化的患病率逐年上升,发病机制复杂,目前在临床上仍缺乏有效的治疗方法。细胞焦亡是一种新发现的细胞程序性死亡过程,在呼吸系统疾病尤其在肺纤维化发病中起重要作用。以焦亡途径为新靶点的研究已经成为热点,现就细胞焦亡在尘肺肺纤维化发生发展中的作用相关研究进行综述。

Abstract: The prevalence of pulmonary fibrosis in pneumoconiosis is increasing year by year, and the pathogenesis is complex. At present, there is still a lack of effective treatment in clinical practice. Pyroptosis is a newly discovered programmed cell death process, which plays an important role in respiratory diseases, especially in the pathogenesis of pulmonary fibrosis. Research targeting the pyroptosis pathway has become a hot topic. This article reviews the related research on the occurrence, development and treatment of pyroptosis in pneumoconiosis with pulmonary fibrosis.